Hepatopulmonary Syndrome
Conditions
Interventions
Case group: Patients with liver disease with HPS:No
Control group: Patients with liver disease without HPS:No
Healthy control group: Patients with normal liver function:No
Sponsors
Department of Anesthesia, Southwest Hospital, the Third Military Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) 40 to 70 years; (2) liver cirrhosis: according to the clinical manifestations, liver function tests, impact studies and pathological examination, the diagnosis of cirrhosis and Child-puge improved grading method was C grade (see Annex); (3) pulmonary microvascular dilation: Contrast enhanced echocardiography by chest showed the cloud and cloud shadow was found in the left ventricle and left atrium in 4 ~ 6 cardiac cycles after intravenous injection of 60 ~ 90µm normal saline; (4) arterial oxygenation function abnormality: standing position, resting blood gas analysis PO2=15 mmHg (greater than 64 year old elderly people>=20 mmHg); (5) preoperative assessment of ASA: I~III grade; (6) patients undergoing elective limb or abdominal surgery; (7) patients voluntarily participated in the study and signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Heart, lung, kidney disease; (2) forced expiratory volume in the first second [FEV1] or forced vital capacity [FVC]<70% forecast, or FEV1/FVC<0.70; (3) a metabolic disease; (4) more than 20% of the ideal body weight; (5) the treatment of an analgesic or a neuro - conditioning drug; (6) the researchers are not suitable for clinical trials because of other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood gas analysis;Hemodynamic parameters;respiratory function parameters;Depth of Anaesthesia;muscle relaxation depth;the dosage of anesthetic, muscle relaxation, analgesic and vasoactive drugs, the amount of fluid volume, blood loss, blood transfusion;postoperative pain score;postoperative adverse reactions; | — |
Countries
China
Contacts
Public ContactKaizhi Lu
Outcome results
None listed