nephrotic syndrome
Conditions
Interventions
1:tacrolimus therapy
Sponsors
The first affiliated hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. SRNS: prednisone (Pre, or its equivalent) at 1-1.5 mg/kg per day remained non-response when treatment was continued for more than 8 weeks, excluding the possible cause such as infections, hypercoagulability or thrombosis; 2. other immunosuppresnt therapy including cyclophosphamide treatment, mycophenolate mofetil therapy, Tripterygium multiglycoside in the treatment of patients received cyclosporine treatment.
Exclusion criteria
Exclusion criteria: 1. known secondary causes for nephrotic syndrome, such as Henoch Schnlein purpura nephritis, Systemic Lupus Erythematosus, Hepatitis B virus-associated nephritis; 2. active infectious disease; 3. Serum creatinine greater than 3mg/dl; 4. Pregnancy, lactation or unwilling to take contraceptive measures; 5. A diagnosis of diabetes mellitus; 6. Known hypersensitivity to macrolides.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| liver function;serum cretinine;blood glucose;blood lipid;blood concentration; | — |
Primary
| Measure | Time frame |
|---|---|
| 24 h urine protein;serum albumin; | — |
Countries
China
Contacts
Public ContactHong Dai
Outcome results
None listed