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Effects of Particulate Air Pollution on Corticosteroid Insensitivity in Patients with Chronic Obstructive Pulmonary Disease: Roles of Histone deacetylases and Autophagy

Effects of Particulate Air Pollution on Corticosteroid Insensitivity in Patients with Chronic Obstructive Pulmonary Disease: Roles of Histone deacetylases and Autophagy

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-OOC-15006761
Enrollment
Unknown
Registered
2015-07-17
Start date
2015-08-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD

Interventions

Case series:Nil

Sponsors

Nil
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 80 Years

Inclusion criteria

Inclusion criteria: COPD patients: Inclusion criteria: 1. Willing and signed informed consent; 2. males or females aged between 40 y/o to 80 y/o; 3. diagnosed with COPD by physicians; 4. FEV1/FVC< 70% predicted.

Exclusion criteria

Exclusion criteria: COPD patients Exclusion criteria: 1. known asthma, bronchiectasis, tuberculosis, pneumoconiosis, or other pulmonary diseases; 2. malignancy; 3. acute exacerbation or infection in 3 months. Normal non-smokers and healthy smokers Exclusion criteria: 1. any acute infections, including upper airway infection, in 3 months; 2. Known major acute or chronic medial diseases.

Design outcomes

Primary

MeasureTime frame
Inflammation;—

Countries

China

Contacts

Public ContactHsiao-Chi Chuang
chuanghc@tmu.edu.tw+886-2-27361661

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026