stress-related diseases
Conditions
Interventions
Sponsors
The First Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
37 Years to 40 Years
Inclusion criteria
Inclusion criteria: The subjects of present study were recruited from workers of Kailuan Mining Group in six coal reserve bases, two communities and two related units. Based on the dates of birth, the study subjects were divided into three groups: infant exposure, prenatal exposure, and no exposure: 1. The inclusion criteria for the infant exposure group were: born and raised in Tangshan; born between July 29, 1975 and April 28, 1976; exposed to the earthquake between 3 to 12 months of age; 2. The inclusion criteria for the prenatal exposure group were: born and raised in Tangshan; born between July 29, 1976 and April 28, 1977; exposed to the earthquake in fetal period; 3. The inclusion criteria for no exposure group were: born and raised in Tangshan; born between July 29, 1977 and April 28, 1978; born 1 to 1.9 years after the earthquake; 4. Healthy controls: the Iron And Steel Works group of Shijiazhuang (1) born and raised in Shijiazhuang; (2)born between July 29, 1975 and April 28, 1978.
Exclusion criteria
Exclusion criteria: The following exclusion criteria were applied: presence of infection, hypertension, epilepsy or seizures, diabetes, thyroid disease, use of medication, drinking history, or other traumatic events in addition to earthquake during pregnancy; any form of mental illness in the past or present; unknown or missing information regarding the pregnancy during earthquake.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IL-1;IL-2;IL-4;IL-6;IL-8;IL-10;IL-12;IL-14;TNF-a;telomere;telomrase; | — |
Countries
China
Contacts
Public ContactXueyi Wang
Outcome results
None listed