Adult Lymphoblastic Leukemia/ Lymphoma
Conditions
Interventions
Case series:Nil
Sponsors
Hospital of Blood Diseases, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. De novo and primary Ph/BCR-ABL1 negative adult lymphoblastic leukemia/ lymphoma patients diagnosed by the bone marrow cytomorphology, immunophenotyping, cytogenetics and molecular biology according to WHO classification; 2. Male or female, Age (years) >=15; 3. ECOG Performance status of 0,1, or 2; 4.Predicted survival time >=3 months; 5.Contraception should be agreed and performed for reproductive age men and women; 6.Patients must have the following laboratory values 1) Total bilirubin 45%; 7. Patient must sign the informed consent prior to study.
Exclusion criteria
Exclusion criteria: 1. Diagnosed as MPAL, Burkitt lymphoma/leukemia according to WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues(2008); 2. Other serious or life threatening diseases:Patients with another primary malignancy (requiring active intervention at the same starting study time);hepatitis, serious pancreatic or kidney disease; 3. Female who are pregnant, breast feeding or childbearing potential; 4. HIV positive patients; 5. Mental disorders which may interfere the patients to sign the informed consent or to complete the treatment; 6. The investigator believe that patient who are not suitable for involvement.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival(OS); | — |
Secondary
| Measure | Time frame |
|---|---|
| DFS;CR rate;EFS;IRM;TRM; | — |
Contacts
Public ContactJianxiang Wang
Outcome results
None listed