cardiac renal syndrome and sepsis
Conditions
Interventions
Case series:NA
Sponsors
Beijing Chaoyang Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: The Heart Failure Group: Selection the patients who is clinical diagnosed acute heart failure (including the in-hospital patients and the new attendance patients), and meet anyone of the followings: The cardiac function of NYHA class III - IV and the value of NT – proBNP over the positive cut-off values of different age (the patients less than 50 years old of 450 pg/ml; 50-75 years old of 900 pg/ml; more than 75 year old of 1800 pg/ml). The cardiac function of Killip class III - IV after acute myocardial infarction and the value of NT – proBNP over the positive cut-off values of different age (the patients less than 50 years old of 450 pg/ml; 50-75 years old of 900 pg/ml; more than 75 year old of 1800 pg/ml). Echocardiographyof LVEF 38.3 degree C); Hypothermia (core temperature 90 bpm or more than 2 SDs above the normal value for age; Tachypnea; Altered mental status; Significant edema or positive fluid balance (>20 ml/kg during 24h); Hyperglycemia (plasma glucose >7.7mmol/L) in the absence of diabetes; Inflammatory Variables: Leukocytosis (WBC >12*10^9/L); Leukopenia (WBC 10% immature forms; Plasma C-reactive protein more than 2 SDs above the normal value; Plasma procalcitonin more than 2 SDs above the normal value. Hemodynamic Variables: Arterial hypotension (SBP 40 mmHg in adults or less than 2 SDs below normal for age); Organ Dysfunction Variables: Arterial hypoxemia (PaO2/FiO2 0.5 mg/dl; Coagulation abnormalities (INR>1.5or APTT>60s); Ileus (absent bowel sounds); Thrombocytopenia (platelet count 70umol/L). Tissue perfusion Variables: Hyperlactatemia (>1mmol/L); Decreased capillary refill or mottling.
Exclusion criteria
Exclusion criteria: The Heart Failure Group: Comply with anyone of the followings: Age <18 years old; Pregnancy; The abnormal renal function of known; Autoimmune diseases; Terminal cancer; Sepsis; The treatment time in emergency <3 days. The Sepsis Group: Comply with anyone of the followings: Age <18 years old; Pregnancy; The abnormal renal function of known; Autoimmune diseases; Terminal cancer; The treatment time in emergency <3 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neutrophil Gelatinase-Associated Lipocalin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cystatin C;N - brain natriuretic peptide precursor;Procalcitonin; | — |
Countries
China
Contacts
Public ContactChun-sheng Li
Outcome results
None listed