Sepsis
Conditions
Interventions
Sponsors
Department of Surgical Intensive Care Unit, Beijing Chao-yang Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. after major operations; 2. >18 years old; 3. length of ICU longer than 7 days; 4. sepsis being confirmed within 7 day after admission to ICU.
Exclusion criteria
Exclusion criteria: 1. age less than 18 years; 2. length of ICU <7 days; 3. sepsis being confirmed on the day of admission to ICU; 4. being pregnant or nursing an infant; 5. immunosuppressive therapy (eg, cyclosporine or azathioprine) or cancer-related chemotherapy; 6. documented or suspected acute myocardial infarction within the previous 6 weeks; 7. HIV infection; 8. not being expected to survive the 7-day observation period or not being likely to be placed on life support because of an uncorrectable medical condition, including a poorly controlled neoplasm or end-stage lung disease; 9. a chronic vegetative state or a similar long-term neurological condition; 10. current participation in any interventional study (of a drug or device); 11. inability to be fully evaluated during the study period and 12. being a study-site employee or a family member of a study-site employee involved in conducting this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the levels of serum calprotectin;immune functions of Treg cells;apoptosis;the expression of TLR4; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patients daily life signs;blood routine examination;blood lactate;PCT;CRP;Mechanical ventilation;apache II score;SOFA score;Length of ICU stay;28 days CFR;Total hospital stay;Total hospitalization expense; | — |
Countries
China
Contacts
Public ContactLi-feng Huang
Outcome results
None listed