the invasive fungal infections
Conditions
Interventions
Sponsors
the Pharmacy Department of the First Affiliated Hospital of the Third Military Medical University, PLA
Eligibility
Sex/Gender
All
Age
18 Years to 88 Years
Inclusion criteria
Inclusion criteria: 1. Older than 18 years old, both men and women. 2. To stay in hospital for more than 120 hours. 3. The patients that clinical diagnosis is invasive fungal infection. 4. The patients that propose to use voriconazole for antifungal therapy for at least 3 days. 5. The subjects (or their legal representatives) have signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Renal insufficiency, creatinine clearance <30 ml/min; 2. Patients with active liver disease or suspected drug liver damage; 3. Patients with mild to moderate liver cirrhosis (Child - Pugh, A and B); 4. Pregnancy and lactation women; 5. Patients that used fluconazole within 72 hours before the use of voriconazole treatment 6. Patients that used rifampicin, ritonavir, carbamazepine, phenobarbital, cimetidine, phenytoin, rifabutin, omeprazole, norethindrone, ethinyl estradiol within 72 hours before or during the use of voriconazole treatment; 7. Merge with other deep antifungal drugs; 8. The patients that are considered not fit into this study by the comprehensive judgment of the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| steady blood drug concentration;the gene type of CYP2C19; | — |
Contacts
Public ContactChen Yongchuan
Outcome results
None listed