postoperative cognitive fuction
Conditions
Interventions
different dosage of propofol groups:different dosage of propofol
different dosage of sevoflurane group:different dosage of sevoflurane
sevoflurane intervention group:sevoflurane
propofol with sevoflurane group:propofol with sevoflurane
Sponsors
The Tianjin Chest Hospotal
Eligibility
Sex/Gender
All
Age
19 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1) elective cardiac surgery; 2) men and women not limited; 3) the participants have signed informed consent.
Exclusion criteria
Exclusion criteria: (1) emergency surgery; (2) preoperative cerebrovascular disease; (3) history of mental illness, long-term use of sedatives and antidepressants; (4) history of pneumothorax; (5) liver and kidney dysfunction; (6) secondary surgery; (7) EF <40%; (8) alcohol; (9) level of education <7 years; (10) serious visual, auditory and language can't communicate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amino acids in the brain;cortisol;interleukin-6;interleukin-10;tumor necrosis factor;neuronspecific enolase;myelin basic protein;superoxide dismutase;malondialdehyde;S100 beta protein;intake and output volume; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood gas analysis;bispectral index;heart rate;blood pressure;oxygen saturation; | — |
Countries
China
Contacts
Public ContactJiange Han
Outcome results
None listed