idiopathic pulmonary fibrosis
Conditions
Interventions
treatment group:subcutaneous injection of Granulocyte colony stimulating factor termly
control group:no processing
Sponsors
Shanghai Pulmonary Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Idiopathic pulmonary fibrosis (IPF) patients are diagnosed according to the 2011 ATS / ERS / JRS / ALAT; 2. Male or female without pregnancy,aged during 50 to 80 years old; 3. Have good compliance, willing to exercise in accordance with the program and follow-up with the schedule; 4. Patients were fully informed of the purpose, method and possible discomfort of the test, agree and signed in consent.
Exclusion criteria
Exclusion criteria: 1. Having serious diseases in other system and organ dysfunction; 2. Having malignant tumor; 3. Participating in other clinical trials within three months; 4. Patients with abnormal renal function: Creatinine value > 1.5 times of the upper limit of normal value; 5. Patients with splenomegaly; 6. Patients With diseases of the blood system; 7. Pregnancy, breast-feeding women, planning to pregnant and those who can not take effective contraceptive measures; 8. There is any unsuitable situation for those selected.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the score of The St George's;times of hospitalization due to the aggravation; | — |
Secondary
| Measure | Time frame |
|---|---|
| lung function (forced vital capacity, carbon monoxide diffusion capacity, the ratio of first second forced vital capacity to forced vital capacity);The changes of high resolution computed tomography;arterial blood gases(Partial pressure of oxygen partial pressure, carbon dioxide, arterial blood oxygen saturation);indicators related to pulmonary fibrosis;End of treatment of pulmonary fibrosis related events (such as the death toll);results of six-minutes walking test; | — |
Countries
China
Contacts
Public ContactHuiping Li
Outcome results
None listed