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Correlation of serum NSE, S-100beta and early postoperative cognitive dysfunction in elderly patients with different depth of anesthesia

Correlation of serum NSE, S-100beta and early postoperative cognitive dysfunction in elderly patients with different depth of anesthesia

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-OOC-15005785
Enrollment
Unknown
Registered
2015-01-05
Start date
2015-01-05
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative cognitive Disfunction

Interventions

Depth of anesthesia:Sevoflurane

Sponsors

First Affiliated Hospital of Medical College of Shihezi University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 80 Years

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists (ASA) grade I~II, expected operating time 3h-6h, years of education more than 6 years; preoperative one day do mini-mental state examination intelligence (MMSE)and the score more than 24 points.

Exclusion criteria

Exclusion criteria: Neurological, psychiatric disorders; a large number of long-term use of sedatives or antidepressants; history of alcohol abuse, drug abuse history, or history of drug dependence; significantly impaired kidney function and cardiovascular disease; have serious hearing, visual impairment or motor abnormalities; weight fluctuation range exceeds the standard weight of thereabout 25%; preoperative testing nonadherence, unable to communicate, as well as those who can not complete the postoperative follow-up.

Design outcomes

Primary

MeasureTime frame
S-100beta;—

Countries

China

Contacts

Public ContactGao Yuanli
gyl1228@sina.com+86 18935700606

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026