End-stage Renal Failure and Insecondary Hyperparathyroidism
Conditions
Interventions
end-stage renal failure and insecondary hyperparathyroidism Group:infusing Dexmedetomidine before anesthesia induction
General patient group:infusing Dexmedetomidine before anesthesia induction
Sponsors
Anesthesia Department of the second hospital of AnHui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Group E: Patients with end-stage renal failure and insecondary hyperparathyroidism, 18-65 years old, BMI less than 30 kg/m2, plan to implement parathyroidectomy and autotransplantation recently; Group C: Patients with no systemic disease,18-65 years old, BMI less than 30 kg/m2, plan to implement excision of adenoma of thyroid recently.
Exclusion criteria
Exclusion criteria: Patients who had serious cardiac, pulmonary hepatic, uncontrolled diabetes, such as difficult airway, asthma, Hepatitis B; gastrointestinal, neurologic, hematologic, or psychiatric disease; significant electrolyte imbalance; or uncontrolled hypo- or hyperthyroidism were excluded. Those with a particular history of disease, including alcohol and drug abuse, allergy of related medicine, taking anticonvulsants constantly, or having drugs which hindering the analysis of HPLC and hypotensors which effecting on alpha 2- adrenoreceptor (e.g. alpha-methyldopa, clonidine, guanfacine or Serpasil).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pharmacokinetics and pharmacodynamics; | — |
Contacts
Public ContactZhang Ye
Outcome results
None listed