FindTrial
Sign In

the imbalance of mTOR mediated autophagy in septic cardiomyopathy and its therapeutic potential

the imbalance of mTOR mediated autophagy in septic cardiomyopathy and its therapeutic potential

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-OOB-17014129
Enrollment
Unknown
Registered
2017-12-24
Start date
2017-12-24
Completion date
Unknown
Last updated
2018-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis induced cardiomyopathy

Interventions

1:rapamycin
2:bafilomycin

Sponsors

Peiking Union Medical College Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
10 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Sepsis: organ dysfunction caused by infection (SOFA=2); 2. Septic shock vasopressor to maintain MAP>65mmHg despite sufficient fluid resuscitation and Lactate >2mmol; 3. SIC 1) EF less than 50% or decrese more than 10%;2) 10 times elevation of cTnI or BNP/NT-ProBNP;3) Pv-aCO2>6mmHg ScvO2<65%; 4. need inotropes.

Exclusion criteria

Exclusion criteria: 1) less than 18; 2) pregnancy; 3) give up treatment; 4) refuse to sign the consent.

Design outcomes

Primary

MeasureTime frame
mTOR;—

Secondary

MeasureTime frame
EF;MSI;cytokines;Biochemical index;DO2, VO2;inotropes;—

Countries

China

Contacts

Public ContactCui Na

Peking Union Medical College Hospital

pumchcn@163.com+86 010 69152300

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 21, 2026