Cirrhosis
Conditions
Interventions
Cirrhosis:Splenectomy plus esophagogastric devascularization
Sponsors
The First Affiliated Hospital of Harbin Medical Universtiy
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) the age of 18 years old or more, or less 70 years old; Gender not limited; (2) the clinical diagnosis of hepatitis b cirrhosis portal hypertension andmassive haemorrhage of upper gastrointestinal tract, surgical treatment for the first time; (3) under gastroscope confirmed severe varicose vein of the esophagus; (4) the Child - Pugh class for A or B, scoring nine points or less; (5) 50*10^9/L or less platelet; (6) voluntarily signed informed consent.
Exclusion criteria
Exclusion criteria: (1) uncontrollable ascites; (2) hepatic encephalopathy grades II-IV hepatorenal syndrome; (3) gastrointestinal bleeding; (4) malignancy; (5) previous gastrointestinal surgery; (6) hypertensiondiabetes mellitusother liver diseasesignificant respiratory or cardiac dysfunction; (7) neurological and psychiatric disorders; (8) receiving any antibiotics during the previous 3 week before specimen collection; (9) thyroid dysfunction; (10) Inflammatory bowel disease; (11) Gastric mucosal atrophy; (12) treatment with gastric acid secretion inhibitors within 7 days before inclusion; (13) using any medication affecting GI motility in 3 days; (14) other gastrointestinal symptoms which can be explained.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal flora diversity;ratio of microbial flora;gastric emptying time;intestinal transit time; | — |
Secondary
| Measure | Time frame |
|---|---|
| 5-HT concentration;Ghrelin;Leptin; | — |
Countries
China
Contacts
Public ContactLiu Yang
Outcome results
None listed