Arteriovenous Malformation
Conditions
Interventions
bleomycin group:intralesional adminstrated bleomycin
Sponsors
Shanghai 9th People's Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
2 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 2-60; 2. With a typical clinical manifestation, coincidental imaging data including CT/MRI, and definitely AVM diagnosis by DSA; 3. The position of the niduses was extracranial, and had not severe vascular communication branches with intracranial vessels according to imaging information; 4. No symptom threatening life such as massive bleeding or heart failure in recent period; 5. No serious underlying systemic disease especially in immune system, respiratory system and circulatory system; 6. Not accepting any therapy in the last 3 months; 7. Ability and willingness to sign an inform consent form after fully understanding the therapeutic strategy and potential risks.
Exclusion criteria
Exclusion criteria: 1. Without a typical clinical manifestation, or having not exactly characters of medical imaging; 2. The nidus was closely connection with intracranial abnormal vessel lesion; 3. Having symptoms threatening life needing to manage immediately; 4. Serious underlying systemic disease requiring treatment until illness either completes therapy or achieves clinical stablility on therapy for at least 6 months before enrolled the study. The systemic diseases include insufficient pulmonary functions(COPD, pneumonia, pulmonary fibrosis and asthma), insufficient cardiac and hepatorenal functions, infection, hemorrhagic tendency, immunologic disease(SLE, urticaria, HIV); 5. Accepting any therapy in the last 3 months including operation or embolization; 6. Refusing to sign an inform consent form after fully understanding the therapeutic strategy and potential risks; 7. Other contraindications of bleomycin including pregnancy, lactation or combining with some other drugs like antitumor drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Digital Subtraction Angiography (DSA); | — |
Countries
China
Contacts
Public ContactXiaoxi Lin
Outcome results
None listed