radiation-induced brain injury in nasopharyngeal carcinoma after radiotherapy
Conditions
Interventions
Interventional group:monosialotetrahexosylganglioside (ganglioside GM1)
control group:None
Sponsors
Sun Yat-sen University Cancer Center
Eligibility
Sex/Gender
All
Age
20 Years to 55 Years
Inclusion criteria
Inclusion criteria: (1) patients who had newly confirmed by pathology, previously untreated nasopharyngeal carcinoma; (2) patients who are the Han nationality, right-handedness; (3) Between the ages of 20 and 55, education level of junior high school or above; (4) patients who will treated by intensity-modulated radiation therapy (IMRT); (5) without any other serious system disease; (6) without intracranial invasion and distant metastasis; (7) without any focal abnormality detected on routine brain MRI examinations; (8) Without a family history of mental illness; (9) without neurological or psychiatric diseases and prior substantial head trauma; (10) Participants who provided written informed consents.
Exclusion criteria
Exclusion criteria: (1) with focal abnormality detected on routine brain MRI examinations; (2) with contraindications to MRI; (3) with other major medical illness; (4) with tumor recurrence or who cannot insist on the IMRT treatment; (5) left-handedness or both-handness; (6) with a history of head injury, neurological or psychiatric diseases; (7) age lower than 20 or greater than 55 years; (8) other major medical illness; (9) hypertension, diabetes; (10) Participants who cannot cooperate to finish the neuropsychological tests.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Score of Montreal cognitive assessment scale;indices of blood oxygenation level dependent;indices of diffusion tensor imaging;indices of high-resolution three-dimensional T1WI; | — |
Countries
China
Contacts
Public ContactXiaofei Lv
Outcome results
None listed