heart failure
Conditions
Interventions
Sponsors
Chongqing Medical University
Eligibility
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Healthy male between 18 and 60 years of age, body weight more than 50kg; 2. Body Mass Index (BMI) between 19 to 24kg/m2; 3. No clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening; 4. Ability to understand and provide written informed consent and voluntary consent to participate in the study; 5. Ability to complete the study in compliance with the protocol.
Exclusion criteria
Exclusion criteria: Any allergic history or history of cardiac, pulmonary, renal, hepatic, gastrointestinal or hematologic abnormality or any other acute or chronic disease. exposure to any investigational medication within 30 days of the first dose of study medication, pregnant or nursing women, women of childbearing potential not using a highly effective method of birth control.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| methylation status of ABCB1 promoter;histone acetylation status at ABCB1 promoter;drug concentration of digoxi; | — |
Contacts
Public ContactWu Lan-Xiang
Outcome results
None listed