acute ischemic stroke
Conditions
Interventions
Control group:Conventional therapy group
Experimental:autologous bone marrow MSC
Sponsors
Guangdong 999 Brain Hospital
Eligibility
Sex/Gender
Male
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. from 40 to 70 years old with full capacity. Volunteered to participate in the clinical trial and can complete the follow-up tests in this study (signed informed consent); 2. Ischemic stroke symptoms of cerebral artery territory ischemia-induced (paralysis side muscle strength reach 0~III level); 3. Within 24 to 72 hours after onset, stable condition; 4. head CT or MRI scans showed no intracranial hemorrhage or any other large area of lesion that may increase the risk of bleeding; 5. non-comatose; 6. The first onset or previous history of stroke, but without sequelae; 7. NIHSS (National Institutes of Health Stroke Scale) scores between 4~25 points.
Exclusion criteria
Exclusion criteria: 1. Patients with TIA, or mild symptoms, or symptoms improved rapidly ,progressing stroke; 2. CT scan showed any bleeding lesions at enrollment; 3. Coma; 4. Undergoing thrombolytic therapy or other clinical trials; 5. Seizures at the beginning of stroke; 6. Blood glucose level less than 2.7 mmol/L or more than 22.2 mmol/L. Blood pressure higher than 24.0/16.0 kPa, without decline after continues treatment; 7. Heart, lung, liver or kidney failure, severe anemia due to blood transfusion. Or have been diagnosed with the disease (such as psychosis), and difficult to complete the study for up to 1 year; 8. Patient or their guardians are unable or unwilling to sign an informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI score;NIHSS score;Rankin score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ashworth spasticity scale score;Digital pain scale score;The Barthel index score;Safety indexes: blood, uring, stool routing test, liver and kidney function test, blood glucosis; | — |
Contacts
Public ContactWenmin Chen
Outcome results
None listed