advanced colorectal cancer
Conditions
Interventions
A:raltitrexed plus oxaplatin
B:raltitrexed plus Irinotecan
Sponsors
The First Affiliated Hospital of Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Confirmed diagnosis of advanced colorectal cancer; 2. Measurable disease according to RECIST criteria version 1.1; 3. To be aged from 18 to 75 years; 4. ECOG performance score 12 weeks; 6. Hematologic function: N >=1.5*10^9/L, PLT >=80*10^9/L, Hb >=90mg/dL; 7. Renal function: within the normal limit; 8. Hepatic function: BIL <=1.5*UNL, ALT/AST <=2.5*UNL (<=5*UNL if accompanied with liver metastasis); 9. Documented informed consent to participate in the trial.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or breast feeding. Women of childbearing age must use effective contraception; 2. Serious cardiovascular disease (congestive heart failure, uncontrollable arrhythmia, unstable angina, myocardial infarction, serious heart valve disease, resistant hypertension); 3. pregnant or lactating woman; 4. Patient participation in other studies; 5. previously treated with raltitrexed; 6. previously treatment without Fluoropyrimidines; 7. uncontrolled brain metastasis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| resonse rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| PFS;DCR;safety; | — |
Countries
China
Contacts
Public ContactXu Nong
The First Affiliated Hospital of Zhejiang University
Outcome results
None listed