Multiple Myeloma
Conditions
Interventions
PCD chemo group:Chemotherapy
PCD plus ASCT group:Chemotherapy plus ASCT
TCD chemo group:Chemotherapy
TCD plus ASCT group:Chemotherapy plus ASCT
Sponsors
The First Affiliated Hospital of Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. aged 18 years to 70 years; 2. In accordance with IMWG2003/WHO 2008 (V4) MM diagnostic criteria and with measurable indicators; 3. The eastern cooperative oncology group fitness score (ECOG) =10g/L and/or 24-hour urine M protein >=200mg; 5. No active infectious diseases; 6. The main organs without serious organic disease (except for renal dysfunction, caused by the disease); 7. The patients have signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. The patients have received anti-myeloma therapy (not including radiotherapy, bisphosphonate therapy, or a single short-term glucocorticoidshormone [i.e., less than or equal to prednisone 40mg / day, 5 day dose]); 2. The patients appear pain or peripheral neuropathy with two or more degree; 3. The patients have a serious thrombotic events; 4. The patients have a major surgery in 30 days; 5. The patients have other malignancy, unless the disease are in a stable situation for more than 3 years; 6. The patients are on borate, mannose, and thalidomide allergies; 7. The patients have serious infectious diseases (not cured tuberculosis, pulmonary aspergillosis); 8. The patients have epilepsy, dementia and other mental health exception demanding drug treatment; 9. There are some stats in the subjects may effect the study or study assessing (i.e., drug abuse, or other medical, psychological or social status); 10. The researchers believe that those who do not fit into this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Allover response rate;Complete response rate;Safety; | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease free survival;Progression free survival;Overall survival; | — |
Countries
China
Contacts
Public ContactZhen Cai
Outcome results
None listed