Primary hepatocellular carcinoma
Conditions
Interventions
Liver transplantation:Liver transplantation combined with ADV-TK gene
The hepatic resection:The hepatic resection combined with ADV-TK gene
TACE+radio frequency:TACE+radio frequency combined with ADV-TK gene
Sponsors
Beijing YouAn Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Liver transplantation: 1) Primary liver cancer beyond Milan criteria, accompanied by hepatic lymph node metastasis; 2) Accompanied by portal vein tumor thrombus, not more than the main portal vein 1/2; 3) Primary liver cancer confirmed by histopathology; 4) Aged 18-70 years old; 5) Signed the informed consent. 2. The hepatic resection: 1) Primary liver cancer; 2) Liver lesions localized to one lobe of liver or half liver can operation resection; 3) Resection range from operation margin <=3cm; 4) Signed the informed consent. 3. TACE+radio frequency: 1) Primary liver cancer; 2) Liver lesions localized to one lobe of liver or half liver; 3) Liver lesions edge from important vascular and biliary <=3cm; 4) Liver lesions can be resected but the patient does not agree with the operation; 5) Signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Allergic to ADV-TK and Ganciclovir or others; 2. After transplantation, the vital signs of the patients' recovery instability; 3. Poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DFS;survival;Control rate; | — |
Contacts
Public ContactNing Li
Outcome results
None listed