cerebral infarction
Conditions
Interventions
Lumbar puncture stem cells therapy:Infusion of umbilical cord mesenchymal stem cells
Control:Using conventional drug therapy, including the application of cerebral protection agent (such as cell two choline and intravenous infusion of 10 d/course), improve microcirculation (Salvia mil
Vein group:Infusion of umbilical cord mesenchymal stem cells
Sponsors
The 105th Hospital of PLA
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Individuals aged 18–80 years of both sexes were eligible for the study if they had the following characteristics: 1. Ischemic stroke in the middle cerebral artery (MCA) territory evidenced by computed tomography or MRI occurring within 14 days; 2. Recanalization of the involved MCA as assessed by transcranial Doppler studies or by magnetic resonance angiography; 3. A score between four and 17 according to the National Institutes of Health Stroke Scale (NIHSS).
Exclusion criteria
Exclusion criteria: 1. Ipsilateral carotid stenosis (>50%,by Doppler studies); 2. Neurological worsening (>four points in the NIHSS) before injection due to either edema or intracerebral hemorrhage; 3. Thrombophilias or primary hematological diseases; 4. Previous stroke with modifed Rankin Scale(mRS) of more than 2; 5. Neurodegenerative disorders; 6. Autoimmune disorders; 7. Intracardiac thrombus; 8. Sepsis; 9. History of neoplasia or other comorbidity that could impact a patients short-term survival; 10. renal failure (serum creatinine >2 mg/ml); 11. Pregnancy or previous participation in other clinical trials; 12. Diffculty in obtaining vascular access for percutaneous procedure; 13. Liver failure;(14)Lacunar stroke;(15)Any condition that in the judgment of the investigator would place the patient under undue risk.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NIHSS-Score; | — |
Countries
China
Contacts
Public ContactQingsong Wang
Outcome results
None listed