Induction of anesthesia
Conditions
Interventions
Low:In this group, the volunteers receive emulsified isoflurane at the dose of 22.63mg/kg
Midddle:In this group, the volunteers receive emulsified isoflurane at the dose of 38.26mg/kg
High dose:The volunteers receive emulsified isoflurane at the dose of 49.73 mg/kg
Sponsors
Yichang HumanWell Pharmaceutical Co.,Ltd
Eligibility
Sex/Gender
All
Age
20 Years to 28 Years
Inclusion criteria
Inclusion criteria: 1) Age 18~45 years old (50:50 male:female) healthy volunteer of American Society of Anesthesiologists (ASA) Physical Classification System status of P1; 2) Body Mass Index (BMI) 19~24 kg/m2; 3) Health volunteers assessed by medical history and physical examination: systolic blood pressure between 90~140mmHg; heart rate between 50~100bpm; pulse oxygen saturation > 95% when inspiring air; normal result for routine lab test, including complete blood count, chemical test, urine test and stool test; norma result for chest X Ray and standard 12-lead ECG; 4) Female subjects of childbearing potential having negative urine pregnancy tests and having been using specified birth control methods prior to dosing; 5) No systematic disease history; 6) Non-smoker and no history of alcohol or drug abuse.
Exclusion criteria
Exclusion criteria: 1) Any history of allergy, especially to isoflurane or lipid emulsion; 2) Any suspected history of malignant hyperthermia in the volunteer or his/her relatives; 3) Hyperlipidemia; 4) Known or expected difficult airway or suspected difficult airway; 5) Recent use of any drug within 2 weeks; 6) Recent participation in other clinical trial (within 1 month); 7) Pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma isoflurane concentration;Safty; | — |
Secondary
| Measure | Time frame |
|---|---|
| exhaled isoflurane concentration; | — |
Countries
China
Contacts
Public ContactJin Liu
Department of Anesthesiology, West China Hospital, Sichuan University
Outcome results
None listed