Non-small cell lung cancer
Conditions
Interventions
1:Chemotherapy combined with AVASTIN
2:Chemotherapy
Sponsors
The first affiliated hospital of Guangzhou MC
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Histological or cytological diagnosis of lung adenocarcinoma histology with brain metastases; 2. 18 years or older; 3. ECOG Performance Status no more than 2; 4. Appraisable disease, the presence of at least three lesions if longest diameter <10 mm by brain MRI; 5. Haemoglobin 10.0 g/dl, Absolute neutrophil count (ANC) 1.5*10^9/L, platelets 100*10^9/L; 6. Total bilirubin 1.5*upper limit of normal (ULN); 7. ALT and AST < 2.5*ULN in the absence of liver metastases, or < 5*ULN in case of liver metastases; 8. Creatinine clearance 60ml/min (calculated according to Cockcroft-gault formula).
Exclusion criteria
Exclusion criteria: 1. Tumor invasion or surrounding the large blood vessels showed by the imaging; 2. Using the full amount drug for inhibition of platelet function now or recently (pre-treatment 10 days), anticoagulants or thrombolytic agent treatment, allowing preventive anticoagulants; 3. Non-healing wounds, active peptic ulcer or fracture; 4. Abdominal fistula, gastrointestinal perforation or intra-abdominal abscess 6 months before first treatment; 5. Be allergic to bevacizumab, gemcitabine or cisplatin; 6. Major surgey or serious trauma 2 months before first treatment; 7. Mixed non-adenocarcinoma cell lung cancer histology.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor ORR; | — |
Secondary
| Measure | Time frame |
|---|---|
| PFS;The rate of pathology down-stage of lymph nodes;pathology CR;The rate of complete rescetion of tumor;Safety;Quality of life; | — |
Countries
China
Contacts
Public ContactJianxing He
Outcome results
None listed