Myelodysplastic synrome
Conditions
Interventions
1:20mg/m2, infused intravenously over 1 hour daily on 5 consecutive days, every 4 weeks 1 course
2:15(±1)mg/m2, infused intravenously over 1 hour daily on 5 consecutive days, every 4 weeks 1 course
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
16 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age range from 16 to 90 years; 2. diagnosis of intermediate/high risk MDS, and IPSS >=0.5; 3. A performance status of 0-2 according to the Eastern Cooperative Oncology Group (ECOG); 4. no evidence of severe concurrent cardiac, pulmonary, neurologic, or metabolic diseases; 5. adequate hepatic (serum bilirubin level <2*upper normal limit) and renal (serum creatinine <2*upper normal limit) function tests; 6. Signed informed consent indicating that patients are aware of the clinical trail of this study.
Exclusion criteria
Exclusion criteria: 1. age 90 years; 2. Female with pregnancy; 3. a performance of 4-5 according to ECOG score; 4. HIV positive; 5. uncontrolled severe fungal infection or tuberculosis; 6. with other progressive malignant diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall response rate (ORR); | — |
Secondary
| Measure | Time frame |
|---|---|
| overall survival;hematological adverse effects;treatment safety; | — |
Countries
China
Contacts
Public ContactLi Xiao
Outcome results
None listed