liver transplantation
Conditions
Interventions
Group 2:experimental group and control group adjust immunosuppressant dosage according to ImmuKnow ATP value (200-300 ng/mL) or tacrolimus trough levels (5-8 ng/mL) respectively
Sponsors
Shanghai Jiao-tong University School of Medicine Renji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Male and female (approximately equal in number), aged from 18-65 years old; 2. Clinically stable liver recipients over 1 year; 3. Living donor or cadaveric liver transplant recipients; 4. Stable liver recipients who can come to outpatient clinic and take blood test regularly; 5. Planned immunosuppressive regimen: according to each transplantation center; 6. Participate in the study voluntarily.
Exclusion criteria
Exclusion criteria: 1. Age 65years old; 2. Post liver transplantation within 1 year; 3. Absolute WBC count less than 2000 per micro liter; 4. Concurrently intake immunomodulating drugs (e.g. Zadaxin, Aweto, Glossy ganoderma); 5. Patient is not eligible for enrollment according to Clinicians' judgment; 6. Withdraw the informal consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of biopsy proven acute rejection (AR) or clinical AR at the endpoint of the trial; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence and time point of acute rejection; frequency of acute rejection; incidence of infection; | — |
Countries
China
Contacts
Public ContactQiang Xia
Outcome results
None listed