Chronic obstructive pulmonary disease (COPD)
Conditions
Interventions
1:Serial Echocardiographic examine the effect of Chronic Obstructive Pulmonary Disease of Early Right Ventricular Dysfunction
Duration of intervention: 5 years
2:The goal of the proposed research project is to examine the effect of chronic obstructive pulmonary disease (COPD) on early occurrence of right ventricular [RV] dysfunction in both systole and diast
Sponsors
RGC funding
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Patients diagnosed with COPD who are stable (without history of acute exacerbation of COPD in the past 3 months before enrolment); and 2) Objective evidence of abnormal and obstructive lung function by spirometry, with FEV1 between 30-80% of normal age-predicted value and FEV1/FVC ratio <70%.
Exclusion criteria
Exclusion criteria: 1) COPD with history of hospitalization due to acute exacerbation within the past 3 months; 2) COPD who are dependent on assisted ventilation of any kind that may affect cardiac function; 3) Patients who have other interstitial lung disease, e.g. pneumoconiosis, bronchiectasis, alveolar fibrosis, etc; 4) Patients with other active lung pathologies, such as primary or secondary lung malignancies, pneumonia, active tuberculosis, pleural effusion, etc; 5) Patients with primary pulmonary hypertension; 6) Patients with secondary pulmonary hypertension other than due to COPD, such as thromboembolism; 7) Patients who known structural heart disease, such as coronary heart disease, left ventricular hypertrophy, significant valvular heart disease, cardiomyopathies, etc; 8) Patients with active cardiac arrhythmias such as atrial fibrillation; 9) Patients with active systemic illness or end-organ disease that may affect cardiac or pulmonary function, such as renal or liver failure; 10) Patients with disease with expected life expectancy <1 year, such as malignancies; 11) Patients who refuse to participate the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patients enrolled into the study will perform baseline assessment that include spirometry with DLCO, ECG, echo (with TDI and 3DE) examination, 6-Minute hall walk test, quality of life by St. Georges Respiratory Questionnaire, and blood test for neurohormones (B-type natriuretic peptides [BNP]), N-terminal Pro-BNP, epinephrine and norepinephrine). The investigation data collected from the Cross-sectional study will also be used as the baseline tests for the Prospective study. Patients will then;Patients enrolled into the study will perform base;Patients enrolled into the study will perform base; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nil;Nil;Ni; | — |
Countries
China
Contacts
Public ContactCheuk Man Yu
Outcome results
None listed