acute ischemic stroke
Conditions
Interventions
tirofiban group:intravenous or intra-arterial tirofiban
Control:Mechanical thrombectomy and drug treatment programs include expansion, control of blood pressure, blood sugar, moderate sedation, etc.
Sponsors
Daping Hospital of Third Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. acute ischemic stroke patients with large artery occlusion detected by CTA or MRA, aged 18 years or older; 2. No evidence of Cardioembolism; 3. Patients presented to ER mores than 4.5 hours from symptom onset, the volume of infarct core less than volume of hypoperfusion area on CTP; 4. Patient or his/her relative was willing to participate in the study and to provide informed consent.
Exclusion criteria
Exclusion criteria: 1) Hemorrhagic transformation; 2) Pre-stroke mRS = 2; 3) History of severe bleeding or major surgery within 30 days; 4) Coexistent terminal illness with life expectancy = 12 months; 5) Any known hereditary or acquired hemorrhagic diathesis, coagulation factor deficiency; 6) taking oral anticoagulant with INR > 1.7; 7) Platelet count < 100,000/mm3; 8) Hemoglobin < 10 g/dL; 9) A serum glucose level= 50 mg/dl; or 10) Severe renal insufficiency with creatinine clearance rate <30ml/min; 11) patient or his/her relative refuses to use tirofiban.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hemorrhagic tranformaiton;mortality;NIHSS at 7 days;times of thrombectomy;time from puncture to TICI2b/3; | — |
Secondary
| Measure | Time frame |
|---|---|
| mRs at 90 days; | — |
Countries
China
Contacts
Public ContactMeng Zhang
Neurology Department of Daping Hospital, Third Military Medical University
Outcome results
None listed