Clinical study of percutaneous renal denervation (RDN) plus implantable cardioverter defibrillator (ICD) in severe heart failure patients with narrow QRS complexes

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-ONN-17012699

Enrollment

Unknown

Registered

2017-09-18

Start date

2015-01-01

Completion date

Unknown

Last updated

2020-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure

Interventions

ICD group:Implantable cardioverter defibrillator (ICD) implantation only

RDN+ICD group:Percutaneous renal sympathetic denervation (RDN) plus implantable cardioverter defibrillator (ICD) implantation

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: (1) Aged over 18 years; (2) chronic severe heart failure patients; (3) left ventricular ejection fraction (LVEF) <40%; (4) QRS < 0.12 s; (5) class of cardiac function by New York Heart Association , in class 3-4.

Exclusion criteria

Exclusion criteria: (1) renal artery stenosis (RAS); (2) glomerular filtration rate <45 mL/min/1.73m2; (3) type 1 diabetes mellitus; (4) severe heart valve disease; (5) pregnancy or intended pregnancy during study period; (6) acute phase of myocardial infarction (MI) or cerebrovascular accidents.

Design outcomes

Primary

Measure	Time frame
LVEF;LV end diastolic diameter;LV end systolic diameter;6 minute walking test;ICD discharge;	—

Secondary

Measure	Time frame
New York Heart Association class;Brain natriutetic peptide;Creatinine;	—

Countries

China

Contacts

Public ContactWei Yang

Department of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine

ywartical@126.com+86 13817057122

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026