cancer pain
Conditions
Interventions
programmable morphine pump in the cisterna magna:the implantation of a programmable morphine pump at the level of the cisterna magna
programmable morphine pump in the thoracic/lumbar subarachnoid space:the implantation of a programmable morphine pump at the level of the thoracic/lumbar subarachnoid space
patient-controlled intrathecal analgesia in the thoracic/lumbar subarachnoid space:the implantation of patient-controlled intrathecal analgesia at the level of the thoracic/lumbar subarachnoid space
Sponsors
Chinese General Hospital of PLA
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The score of visual analogue scale = 7; 2. Inadequate analgesia by high dose oral opioids (equivalent to morphine 400mg/d) or intolerable side effects; 3. life expectancy = 3 months; 4. The results of screening test were positive; 5. High tolerance of general anesthesia; 6. Besides the above criteria (1-5), patients in cisterna magna group also had upper thoracic or cervical tumor/metastases; 7. Besides the above criteria (1-5), patients in conventional region group also had neither upper thoracic nor cervical tumor/metastases.
Exclusion criteria
Exclusion criteria: 1. Allergy to opioids; 2. Puncture site with infection; 3. With anticoagulant therapy or coagulation disorders; 4. With Brain metastases, paraplegia or other serious diseases; 5. Communication disorders or cognitive impairment ; 6. Significant obstruction of the spinal canal by the tumor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain intensity by VAS score;life quality assessment by SF-36 score;morphine usage before operation (converted to oral morphine);morphine usage from pump in 24h after operation (VAS score<3);depression assessment by SDS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| side effects; | — |
Countries
China
Contacts
Public ContactYonghai Sun
Chinese General Hospital of PLA
Outcome results
None listed