Hepatocellular carcinoma
Conditions
Interventions
DEB-TACE group:Doxorubicin(Epirubicin\Pirarubicin)-eluting beads (CalliSpheres) TACE
cTACE group:conventional (microspheres plus lipiodol-doxorubicin) TACE
Sponsors
The First Hospital Affiliated to Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged from 18 to 75, male or female; 2. Histopathological or clinical diagnosis of hepatocellular carcinoma( Reference for the updating of clinical guidelines for hepatocellular carcinoma released by AASLD in 2010); 3. Advanced and unresectable hepatocellular carcinoma,a single nodule or less than 3 tumor nodules, and the nodule size is less than 7cm; 4. Primary tumors have not been treated or without intervention (TACE, iodine therapy) in a year or recurrence after surgery / ablation; 5. Expected survival time is longer than three months; 6. Good liver function (Child-Pugh grade A or grade B for 7 points), hematology index and renal function is normal; 7. ECOG score is less than or equal to 1 point; 8. Understand and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Distant metastasis of tumor; 2. TACE or iodine particle therapy within a year; 3. Obvious arteriovenous fistula; 4. Patients who have had or are now concurrent with other malignant tumors (except for those that have been cured of basal or squamous cell skin cancer or cervical carcinoma in situ); 5. A major disease history of the heart, kidney, bone marrow, or lung, central nervous system involvement; 6. Patients who need antibiotic therapy due to the recent infection; 7. Patients who participate other clinical trials of drugs or devices within four weeks; 8. Complications or social environment that can lead to the failure of the subjects to follow the study plan and even endanger the safety of the patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RR;DCR; | — |
Secondary
| Measure | Time frame |
|---|---|
| OS;TTP;THP;TEP;DQOL; | — |
Countries
China
Contacts
Public ContactJunhui Sun
The First Hospital Affiliated to Zhejiang University
Outcome results
None listed