Retinitis pigmentosa,corneal ulcer
Conditions
Interventions
RP control group:No treatment
RP treatment group:autologous mesenchymal stem cells treatment
CU control group:eye drops
CU treatment group:autologous limbus stomal stem cell tratment
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (RP patients)Inclusion Criteria: 1. Male ageed 45-60 years, male; 2. Retinitis pigmentosa patients with similar vision of both eyes; 3. History of night blindness, disease history more than 5 years; 4. Retinal fundus: bone cells or irregular pigmentation, shrink color of optic disc, macular pardon area (no pigmentation); 5. Vision field< 20 degree, and electroretinogram (ERG) showed a significant decrease of volatility of b wave; (Corneal ulcer patients) Inclusion Criteria: 1. Male and female aged 18-70 years; 2. Corneal ulcer of both eyes with similar vision; 3. Corneal appearance: corneal ulcer under the slit lamp, stromal layer was involved; corneal endothelial was in good condition.
Exclusion criteria
Exclusion criteria: (RP patients)Exclusion Criteria: 1. monocular or secondary RP, nystagmus, high myopia, macular edema in OCT, a serious eye disease (cataract, cornea degeneration), previous eye surgery and eye conditions that influenced the results observed can't follow up; 2. Systemic disease (asthma, heart failure, myocardial infarction, liver failure, kidney failure and other major diseases); serious adverse reaction and systemic diseases during the follow-up period. (Corneal ulcer patients) Exclusion Criteria: 1. Conjunctivitis, keratitis in acute period, a serious eye disease (cataract, cornea degeneration), previous eye surgery and eye conditions that influenced the results observed; 2. can't follow up; 3. Systemic disease (asthma, heart failure, myocardial infarction, liver failure, kidney failure and other major diseases); serious adverse reaction and systemic diseases during the follow-up period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Acuity;Corneal ulcer diameter;anterior chamber; | — |
Countries
China
Contacts
Public ContactFang Wang
Shanghai Tenth People's Hospital
Outcome results
None listed