Cancer pain
Conditions
Interventions
Experiment Group:Fentanyl transdermal patch 12.5ug q72h
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Aged =18 years old; (2) body weight greater than 45Kg; (3) patients with malignant tumors, with clear pathologic evidence; (4) PS 0-3; (5) moderate to severe cancer pain (NRS = 4 points); (6) the expected survival time is greater than 3 months; (7) Non-radiotherapy or pain sites are not irradiated; (8) Opioids are not tolerated; (9) voluntarily join the study and sign informed consent.
Exclusion criteria
Exclusion criteria: (1) the pain of the subject is associated with acute tumor emergency such as intestinal obstruction / perforation, spinal cord compression, epidural metastasis, or weight-bearing bone fractures. (2) In addition to the analgesic drugs, treatment received in the first one month of the group (such as bisphosphonates, chemoradiotherapy, targeted therapy, interventional therapy, etc.) was determined by the researchers to produce a direct pain relief effect; (3) history of drug abuse, history of drug addiction or severe alcoholism; (4) history of psychotropic drug dependence; (5) Opioid allergy; (6) Chronic obstructive or other pulmonary disease; (7) Brain trauma and intracranial hypertension; (8) Heart attack patients with bradycardia; (9) hepatic insufficiency (ALT=2.5×ULNAST=2.5×ULNTBIL=1.5×ULN), renal insufficiency (Cr=2.5×ULN),Except for liver and renal primary tumor; (10) Fever or in vitro heat; (11) Pregnant, lactating women; (12) Transdermal patch release> 48 hours or 24 hours before the next assessment; (13) The researchers found it inappropriate to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy;safety;Quality of Life;Cognitive function; | — |
Countries
China
Contacts
Public ContactLiu Yong
Xuzhou Central Hospital
Outcome results
None listed