Aplastic Anemia
Conditions
Interventions
Case series:Post-Transplant Cyclophosphamide Combined with Short-Term Methotrexate
Sponsors
Xiangya Hosptial of Central South University
Eligibility
Sex/Gender
All
Age
2 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. aged 2 to 65 years (including 2 and 65 years); 2. severe aplastic anemia or transplansion dependant aplastic anemia by Camitta criteria; 3. No HLA matched sibling or unrelated donor,or requiring prompt transplantation without finding HLA consistent donor opportunities; 4. sign informed consent.
Exclusion criteria
Exclusion criteria: 1. The physical fitness score is less than 70 points; 2. HCT specificity prognostic index (HCT-CT) was greater than 4 (including 4 points); 3. uncontrolled viral, bacterial, and fungal infections (progression of disease during antifungal therapy); 4. HIV seropositive; 5. malignant tumor; 6. pregnant and lactating women; 7. men and women who do not agree to contraception during the trial period; 8. researchers believe that patients are not eligible for clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| over survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of aGVHD;Incidence of regimen-related mortality;incidence of chronic GVHD;Sustained engraftment; | — |
Countries
China
Contacts
Public ContactBin Fu
Xiangya Hosptial of Central South University
Outcome results
None listed