Breast cancer
Conditions
Interventions
Observational Group:Non-interventional
Sponsors
National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 years old or more; 2. Breast cancer with synchronous or metachronousmetastases.Histopathologic or cytopathologic confirmed invasive breast cancer with regional lymph node metastasis; 3. Metastasis and/or primitive tumor (in case of synchronous metastases) accessible to biopsy and/or surgery sample; 4. No clinical evidence of other malignancy, unstable complication or uncontrolled infection; 5. Life expectancy > 12 months.6.Informed and signed consent by the patient.
Exclusion criteria
Exclusion criteria: 1. Not accessible to biopsy and/or surgery sample; 2. Patient already enrolled in an other clinical trial with another first line of chemotherapy; 3. Unmeasurable locally advanced (incurable) or metastatic lesion(s), according to RECIST 1.1 criteria; 4. Women who are pregnant, plan to become pregnant or are lactating during the study; 5. Elevation of carcinoembryonic antigen (CEA)observed without distal metastases found; 6. Have some kind of contraindications for chemotherapy and targeted therapy: cardiovascular and cerebrovascular diseases; liver and kidney function deficiency;hematological system diseases;clinician consider the patients are not suitable for chemotherapies or target therapies; 7. Have other malignant tumor previously; 8. Have surgical contraindications:anesthesia taboo;surgery unresectable extensive lesions; 9. State of health can't finish the study; 10. Patient already enrolled in an other clinical trial with another anti-cancer therapy or plan to participate in other clinical study. 11.No self-determination or refuse to participants. 12. With unlisted exclusion criteria but researchers consider not suitable for the clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Size of residual infiltration lesions; | — |
Countries
China
Contacts
Public ContactBailin Zhang
National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Outcome results
None listed