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The observation of joint function change rule on children with severe hemophilia A in different treatment conditions

The observation of joint function change rule on children with severe hemophilia A in different treatment conditions

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-ONC-17011186
Enrollment
Unknown
Registered
2017-04-19
Start date
2017-05-01
Completion date
Unknown
Last updated
2017-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hemophilia A

Interventions

Case series:different treatments

Sponsors

Nanfang Hospital, Southern Medical University, Guangzhou, China
Lead Sponsor

Eligibility

Sex/Gender
All
Age
4 Years to 12 Years

Inclusion criteria

Inclusion criteria: 1. Children with severe hemophilia A (FVIII:C<1%); 2. Aged from 4 to 12 years old; 3. Expose day is more than 100 days; 4. Antibody is negative; 5. Treatment with blood-borne clotting factor VIII or recombinant coagulation factor VIII; 6. Wihtout history of operation on the joints or synovial

Exclusion criteria

Exclusion criteria: 1. Antibody is positive or there is a history which antibody is positive; 2. With infectious diseases such as hepatitis b, hepatitis c, HIV and syphilis, other bleeding and clotting disorders such as ITP; 3. There is a plan to operate on the joints or synovial during the follow-up period (except emergency).

Design outcomes

Primary

MeasureTime frame
an ultrasound examination of joints;HJHS examination of joints;MRI examination of Target joints or double knee joints;—

Countries

China

Contacts

Public ContactJing Sun

Nanfang Hospital, Southern Medical University, Guangzhou, China

JINGSUN.CN@gmail.com+86 13316202696

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026