aplastic anemia
Conditions
Interventions
haplo-HSCT:haplo-HSCT
HSCT:HSCT
Sponsors
Department of Hematology, General Hospital of the Air Force
Eligibility
Sex/Gender
All
Age
2 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. SAA, including patients with type I and type II SAA; 2. between the ages of 1-50 years old, male or female; 3. families signed the informed consent and donor signed the hematopoietic stem cell donation consent; 4. non HLA matched donor; 5. severe transfusion dependent patients; 6. invalid immunosuppressive therapy or relapse; 7. with follow-up conditions.
Exclusion criteria
Exclusion criteria: 1. PNH or Fanconi aplastic anemia; 2. chromosomal analysis showed clonal disease; 3. major organ dysfunction; 4. tumor and the serious infectious diseases; 5. severe infection; 6. others not suitable for Haplo-HSCT.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Platelet engraftment rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neutrophil engraftment;Graft-versus-host disease;Infection and transplantation related mortality;3-year OS; | — |
Countries
China
Contacts
Public ContactWang Hengxiang
General Hospital of the Air Force
Outcome results
None listed