hematologic malignance
Conditions
Interventions
Hematopoietic stem cell transplantation group:Reduced-intensity conditioning regimen related HLA-haploidentical non T cell-depleted in vitro peripheral hematopoietic stem cell transplantation
Sponsors
Hematologic disease center,First Affiliated Hospital of XinJiang Medical University
Eligibility
Sex/Gender
All
Age
14 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 50 to 65 years old with hematologic malignancies; 2. Patients who is below 50 years old have the fellowing situtation: 1) Patients have an urgent need for transplantation, but with uncured infection. Exp. Patiens have Tuberculosis with residual lesions after anti-TB treatment at 6-9 months, or with standard anti-TB treatment over 3 months; Patiens have remaining infection lesions after infection of bacterial and fungal but stable condition; 2) Organ disfunction: Patients have cardiovascular, respiratory system disease, and dysfunction of liver and kidney who is evaluated to tolerated to RIC-RHNT-PBSCT; 3) Patients can not received MAC transplantation whose bodies are also weaker for some reason.
Exclusion criteria
Exclusion criteria: 1. Patient who is over 65 years old; 2. Patients who suffer uncontrollable infection; 3. Patiens with severe cardiovascular,respiratory system disease and dysfunction of liver and kidney; 4. Patients with mental disease; 5. Patients who refuse to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Engraft rate;Acute graft versus host disease;The cumulative incidence of infection;Costimulatory molecules;Basic immunologic function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Chronic graft versus host disease;Overall Surviver;Disease free survival;Transplantation related mortality;Relapse rate; | — |
Countries
China
Contacts
Public ContactMing Jiang
Hematologic disease center, First Affiliated Hospital of Xinjiang Medical University
Outcome results
None listed