hematologic malignancies patients with PES after umbilical cord blood transplantation
Conditions
Interventions
Patients without PES:No
PES without risk factors:MP 0.5mg/kg/d
PES with 1 score:MP 1mg/kg/d
PES with 2 scores:MP 2mg/kg/d
Sponsors
Anhui Provincial Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosed with hematologic malignancies, any age, any gender, any race; 2. No HLA matched sibling donor or unwilling to choose HLA matched sibling donor transplantation; 3. No severe organ failure and active infection; 4. Patients and their families voluntarily carried out UCBT and signed informed consent; 5. If PES occures, patients and their families voluntarily carry out different doses of MP stratified intervention treatment and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Serious viscera dysfunction or disease, such as serious diseases and function disorder in heart, liver, kidney and pancreas; 2. Patients with pregnancy; 3. Participants and/or authorized family members refused to accept UCBT; 4. Researchers believe that can damage the unnecessary risks to safety, make the results of the study subjects any life-threatening illness, condition or organ system dysfunction; drug dependence; uncontrolled mental disease; cognitive impairment; 5. Participate in other similar clinical researches in 3 months; 6. Researchers think that the patient doesn't fit into the group (e.g., patients are expected to be discontinue because of funding problems).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 180d transplant related mortality (TRM); | — |
Secondary
| Measure | Time frame |
|---|---|
| Cumulative incidence of acute GVHD;relapse rate;one year overall survival;one year leukemia free survival;Cumulative rate of neutrophil engraftment;Cumulative rate of platelet engraftment;neutrophil engraftment time;platelet engraftment time; | — |
Countries
China
Contacts
Public ContactZimin Sun
Anhui Provincial Hospital
Outcome results
None listed