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The effect and mechanism research of erythropoietin joint hypothermia treatment the neonatal hypoxic-ischemic brain damage

The effect and mechanism research of erythropoietin joint hypothermia treatment the neonatal hypoxic-ischemic brain damage

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-ONC-16008744
Enrollment
Unknown
Registered
2016-06-29
Start date
2016-07-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

neonatal hypoxic-ischemic brain damage

Interventions

1:EPO joint hypothermia treatment
2:hypothermia treatment
3:EPO alone

Sponsors

Zhongda hospital, Southeast University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) Gestational age greater than or equal to 37 weeks and less than 42 weeks, severe asphyxia, Umbilical cord blood: PH<7.0 and BE<-15, Apgar score <=3 lasts for 5 min; (2) Multiple organ failure, must include neurological damage or disturbance of consciousness, and abnormal muscle tone.

Exclusion criteria

Exclusion criteria: (1) Congenital genetic metabolic diseases, congenital nervous system malformations, congenital malformations involving the cardiopulmonary function; (2) Children with unstable vital signs because of severe infection; (3) Gestational age less than or equal to 37 weeks.

Design outcomes

Primary

MeasureTime frame
cerebral hemodynamics;Brain imaging change;Myocardial enzymes;Hepatic function;—

Countries

China

Contacts

Public ContactLi Huang

Zhongda hospital, Southeast University

hhuangli@hotmail.com+86 13951665570

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026