Esophageal carcinoma, colorectal carcinoma, hepatocellular carcinoma, intrahepatic cholangiocarcinoma and pancreatic carcinoma
Conditions
Interventions
Esophageal carcinoma:CAR-T
Colorectal carcinoma:CAR-T
Hepatocellular carcinoma:CAR-T
Intrahepatic cholangiocarcinoma:CAR-T
Pancreatic carcinoma:CAR-T
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Esophageal carcinoma and colorectal carcinoma 1) High expression of EpCAM by immunochemistry in esophageal carcinoma (squamous cell carcinoma) and colorectal carcinoma (adennocarcinoma); 2) Patient who lack of the indication of surgery or refuse to accept another sugery for the recurrence of tumor after the previous surgery; 3) Age 30-75 years old; 4) Estimated survival > 6 months; 5) Complied with endoscopy procedure; 6) The patients and their relatives fully understand the goal and probable risks of the therapy, and are willing to sign the consent. Hepatocellular carcinoma, intrahepatic cholangiocarcinoma and pancreatic carcinoma: 1) High expression of EpCAM by immunochemistry in hepatocellular carcinoma, intrahepatic cholangiocarcinoma and pancreatic carcinoma; 2) Patient who lack of the indication of surgery or refuse to accept another sugery for the recurrence of tumor after the previous surgery; 3) Aged 18-75 years old; 4) Estimated survival > 6 months; 5) Complied with endoscopy and intervention procedure; 6) The patients and their relatives fully understand the goal and probable risks of the therapy, and are willing to sign the consent.
Exclusion criteria
Exclusion criteria: Esophageal carcinoma and colorectal carcinoma 1) Severe malnutrition (BMI<18); 2) Accompanied with underlying conditions which require the systemic administration of immunosuppressors or Glucocorticoids; 3) Uncontrolled prevailing infection; 4) HIV positive; 5) Active viral hepatitis; 6) Pregnant or breeding women; 7) Refusing to take any contraceptive measure during the therapy and follow-up; 8) Severve underlying systemic conditions involving heart, lung, kidney, brain and hematopoietic system. Hepatocellular carcinoma, intrahepatic cholangiocarcinoma and pancreatic carcinoma: 1) Severe malnutrition (BMI<18); 2) Accompanied with underlying conditions which require the systemic administration of immunosuppressors or Glucocorticoids; 3) Uncontrolled prevailing infection; 4) HIV positive; 5) Active viral hepatitis; 6) Pregnant or breeding women; 7) Refusing to take any contraceptive measure during the therapy and follow-up; 8) Severve underlying systemic conditions involving heart, lung, kidney, brain and hematopoietic system.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Constitutional symptoms;Vital signs;Routine laboratory tests;Endoscopy;Imaging;Ratio of CAR-T cell;Imflammatory factors; | — |
Countries
China
Contacts
Public ContactChengwei Tang
Department of Gastroenterology, West China Hospital, Sichuan University
Outcome results
None listed