hepatocellular carcinoma
Conditions
Interventions
Case series:operation resection combined with radiofrequency ablation therapy
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
16 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) compensation cirrhosis (Child A grade); 2) Multiple liver lesions: must also meet the following three conditions: A. Preoperative combined with medical history, physical examination, laboratory examination, imaging and the final clinical diagnosis for hepatocellular carcinoma; B. To further confirm the number and size of focal lesions using contrast-enhanced ultrasound in operation; C. Pathological diagnosis after operation for primary hepatocellular carcinoma; 3) Preoperative imaging findings should also meet the following two conditions: A. Whether the main location, size, still feasible operation excision, including half liver resection or partial resection;B. Operation before imaging revealed in semi hepatectomy, other lesions smaller than 3cm in diameter, number of less than 2, or in the local mass resection, other lesions smaller than 3cm in diameter, number of less than 3; 4) Preoperative CT or MRI, ultrasound contrast imaging examination were not found in the main portal vein tumor thrombus of portal left, right, trunk or two branches in imaging tumor thrombus, need to do the corresponding half liver or local resection to clear tumor thrombus; 5) No evidence of extrahepatic metastasis; 6) Willing to participate in this clinical study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1) Under the age of 16 patients; 2) Women during pregnant stage and breast-feed stage; 3) Existence of vena cava tumor thrombus, portal vein or hepatic portal vein to retain side of cancer embolus; 4) Imaging studies revealed cirrhosis is heavy, or the Child B level, C level and liver function in patients with liver cancer resection was difficult to tolerate; 5) The complications of heart, lung, kidney and other organs of serious disease, the patients who cannot tolerate operation; 6) The presence of other treatment contraindications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor size;The number of tumor;AFP;Portal vein tumor thrombus;grades of cirrhosis;Total bilirubin;Alanine aminotransferase;Albumin;Prothrombin time;activeated partial thromboplastin time;pathologic stages of tumou; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemoglobin;PLT;serum creatinine;age; | — |
Contacts
Public ContactBo Li
Outcome results
None listed