Phase II Trial of neoadjuvant chemotherapy with Epirubicin, Cisplatin and S-1 for Locally Advanced Gastric Cancer

Status

Recruiting

Phases

Phase 2

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR-ONC-14004666

Enrollment

Unknown

Registered

2014-05-13

Start date

2014-05-26

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastric Cancer

Interventions

Test group:Chemotherapy with Epirubicin,Cisplatin and S-1

Eligibility

Sex/Gender

Male

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. 18-75 years old adult patients, sex not limited;2. ECOG score 0-1;3. Histopathological and / or cytology diagnosis of gastric cancer;4. Preoperative endoscopic ultrasonography and CT or MRI image credit T4 or N+, surgical evaluation for potentially resectable and patients tolerated the operation;5. According to the RECIST 1.1 standard with at least one measurable objective tumor lesions, spiral CT examination, the maximum diameter shall be greater than or equal to 1cm, CT or MRI, the maximum diameter shall be greater than or equal to 2cm;6. Assessment of liver function reserve feasible chemotherapy and bone marrow function;7. No obstruction or digestive tract hemorrhage department of internal medicine can not deal with;8. Not received any chemotherapy naive patients;9. Patients volunteered to participate in, and signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. Less than 18 years of age or older than 75 patients; 2. ECOG Score>1; 3. Preoperative imaging suspicious or distant peritoneal metastasis; 4. Existing chemotherapy taboo or relative contraindications; 5. Serious digestive tract bleeding that is not suitable for the clinical research; 6. Endoscopic tumor into deep ulcer, perforation risk high; 7. Patients with serious cardiovascular disease, liver and kidney dysfunction, pulmonary disease, nerve system diseases or acute infection (infection caused by 38 ? heating); 8. Patients with poorly controlled hypertension or diabetes; 9. Women with pregnancy and lactation; 10. Patients in child-bearing period (men or postmenopausal women less than 1 years) are not willing to take contraceptive measures.

Design outcomes

Primary

Measure	Time frame
Objective respons;Objective response;	—

Countries

China

Contacts

Public ContactQiu Meng

691702993@qq.com+86 18980601776

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026