A study to evaluate the effect of intensive statin on subclinical atherosclerosis lesions by intravascular ultrasound

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR-ONC-14004265

Enrollment

Unknown

Registered

2014-02-13

Start date

2014-02-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute coronary syndrome

Interventions

intensive statin:rosuvastatin 20mg

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged between 18 to 75 years old. The angiographic luminal diameter narrowing in any coronary vessals (without intervention) is beween 40%-70%; 2. statin-naive, defined as receiving no statin therapy within 3 months.

Exclusion criteria

Exclusion criteria: 1. have received statin therapy within 3 months; 2. the angiographic luminal diameter narrowing in any coronary vessals is more than 70%; 3. active liver diseaseany aminopherase =3*ULN; 4. renal function damage,CrCl<30ml/min; 5. myopathy; 6. pregnancy, lactation female; 7. using ciclosporin; 8. patients with uncontrolled triglyceride levels TG=5.65 mmol/L; 9. poorly controlled diabetes (HbA1c=10%).

Design outcomes

Primary

Measure	Time frame
total plaque volume;percent atheroma volum;	—

Secondary

Measure	Time frame
MCP-1;VCAM-1;ICAM-1 mRNA;CCR2 mRNA;hsCRP;LDL-C;HDL-C;TC;	—

Countries

China

Contacts

Public ContactHui Chen

Cardiovascular Department, Beijing Friendship Hospital

chenhui72@medmail.com.cn+86 13910710028

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026