Hypertension
Conditions
Interventions
1:Nifedipine Controlled Release Tablets
Sponsors
the Second Hosptial of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Female or male aged between 18-75 years; 2. Agreed and signed informed consent; 3. 24-hour ambulatory blood pressure monitoring diagnosed with high blood pressure,(during the daytime> 140/90mmHg, nighttime> 125/75mmHg), except white coat hypertension; 4. Clinic blood pressure levels: 160mmHg > SBP >=140mmHg, or 100 mmHg >DBP >=90mmHg; 5. Ankle-brachial pulse wave velocity >=12m/s.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women;Note:Women of reproductive age are required to attend urine pregnancy test before the first sudy and take contraceptive measures during the test; 2. The patients who participated in other clinical trials in less than three months; 3. The patients who had participated in the study; 4. The patients who not be tolerated with nifedipine or its components; 5. Researchers believe that the patient is not suitable for participating in this study; 6. Moderate to severe hypertension. DBP >=100 mm Hg and/or SBP >=160 mmHg; 7. The patient who are taking any kind of antihypertensive drugs; 8. The patients's concomitant treatment containing a cytochrome P450-3A4 inhibitor or inducer; 9. Secondary hypertension; 10. History of cardiogenic shock; 11. The patient who had myocardial infarction or unstable angina within the past six months; 12. Severe valvular disease; 13. The patients who had or have serious heart rhythm abnormalities or conduction disorders; 14. The patients who had crebral ischemic events within the past 12 months; 15. The patients who have intracranial hemorrhage or subarachnoid hemorrhage in the past 12 months; 16. Type 1 or type 2 diabetes; 17. The patients who have gastrointestinal disorders which may cause malabsorption; 18. The patients who have severe gastrointestinal tract constriction or KOCK vesicle; 19. The patients who have liver disease, or AST / ALT higher than three times; kidney failure, creatinine higher than 2.0mg/dl; urine protein (+); 20. The patient who have malignant disease, psychogenia, alcoholism or drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PW; | — |
Secondary
| Measure | Time frame |
|---|---|
| SBP/DBP;Heart Rate; | — |
Countries
China
Contacts
Public ContactWei Cui
the Second Hosptial of Hebei Medical University
Outcome results
None listed