skin squamous cell carcinoma in situ & superficial basal cell carcinoma
Conditions
Interventions
photodynamic therapy group:Each lesion soaked consecutively with 0.5ml ALA solution for 3 hours, which containing 118mg ammonia ALA hydrochloride) . Then uses helium-neon laser irradiate the lesion 20
Sponsors
Institute of Dermatology, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Aged 18 to 75 years, male or female. Diagnosed with squamous cell carcinoma in situ skin or skin superficial basal cell carcinoma. Less than 3 Lesions. The diameter of each lesion not exceeding 4cm; Not received other local and systemic therapy in the two weeks prior to enrollment; Voluntarily participate in this study, and signed informed consent.
Exclusion criteria
Exclusion criteria: Where have any of the following conditions must be excluded subjects who entered the clinical studies: Not filled informed consent; Total number of lesions exceeds 3; Single lesion’s diameter larger than 4cm; Known to have skin photoallergy, porphyria; Known allergies to the study drug (porphyrin) and the similar chemical structure drugs; Lesion complicated with other obvious illness may affect the efficacy evaluation; Patients with physical scars or scarring tendency; Known to have severe immune dysfunction, or long-term use of corticosteroids and immunosuppressive agents; patients with severe heart, liver or kidney disease; With hereditary or acquired coagulation disorders; With serious neurological, psychiatric or endocrine disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Regression of lesion;Recurrence rate;Blood-routine;urine-routine;blood biochemical examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin pathology examination; | — |
Countries
China
Contacts
Public ContactWeida Liu
Institute of Dermatology, Chinese Academy
Outcome results
None listed