Intracranial atherosclerotic artery stenosis
Conditions
Interventions
medical group:drug therapy
Sponsors
Department of Neurosurgery, Changhai Hospital,Second Military Medical University
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. TIA or nonsevere ischemic stroke within 30 days of enrollment; 2. Modified Rankin scale score of =30 years; 5. The clinical symptoms is associated with the target lesion; 6. Patient is willing and able to return for all follow-up visits required by the protocol and available by phone; 7. Patient understands the purpose and requirements of the study, can make him/herself understood, and has provided informed consent.
Exclusion criteria
Exclusion criteria: 1. Tanderm extracranial or intracranial stenosis (50-99%) that is proximal or distal to the target intracranial lesion at the anterior cirulation; 2. Branches of distal vascular stenosis at the anterior cerebral artery, middle cerebral artery, or posterior cerebral artery; 3. Intracranial or extracranial arterial stenosis related to arterial dissection, Moya-Moya disease, radiation-induced vasculopathy, vasculitis or fibromuscular dysplasia; 4. Presence of any of the following unequivocal cardiac sources of embolism: chronic or paroxysmal atrial fibrillation, mitral stenosis, mechanical valve, endocarditis, intracardiac clot or vegetation, myocardial infarction within 3 months, dilated cardiomyopathy, left atrial spontaneous echo contrast; 5. Known allergy or contraindication to aspirin or warfarin, for example, active peptic ulcer disease, major systemic hemorrhage within 30 days, active bleeding diathesis, platelets1.5, clotting factor abnormality that increases the risk of bleeding, current alcohol or substance abuse, uncontrolled severe hypertension (systolic BP>180 mm Hg or diastolic BP>115 mm Hg), severe liver impairment (AST or ALT>3 times normal, cirrhosis), creatinine>3.0 (unless on dialysis); 6. Indication for warfarin or heparin beyond enrollment; 7. Severe neurologic deficit that renders the patient incapable of living independently; 8. Comorbid conditions that may limit survival to <5 years; 9. Pregnancy or of childbearing potential and unwilling to use contraception for the duration of this study; 10. Enrollment in another study that would conflict with the current study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ischemic event; | — |
Countries
China
Contacts
Public ContactJian-min Liu
Outcome results
None listed