Hypertension
Conditions
Interventions
HIFU Treatment Group:Renal sympathetic denervation by using the extracorporeal HIFU
Sponsors
The Second Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years, either sex; 2. the blood pressure can not reached the standard though have received and adhered to full doses of at least three antihypertensive drugs (include a diuretic), or can not tolerate the medications; 3. estimated glomerular filtration rate (eGFR) of >=45mL/min; 4. agrees to have the study procedure(s) performed and additional procedures and evaluations; 5. To be have competent and willing to provide written, informed consent to participate in this clinical study.
Exclusion criteria
Exclusion criteria: 1. pregnant woman, or planning to pregnant; 2. has a history or prior renal artery angioplasty; 3. has an implantable cardioverter defibrillator (ICD) or pacemaker; 4. has experienced MI or unstable angina pectoris within 6 months; 5. has experienced CVA within 6 months; 6. has hemodynamically significant valvular heart disease; 7. has respiratory failure requiring respiratory support; 8. has pyelolithiasis or ureteral calculus; 9. Obesity and renal arteries can not be clearly showed by the ultrasonic apparatus of Model-JC system; 10. with Type 1 diabetes; 11. has known, unresolved history of serious drug allergy; 12. have no legal capacity or legal capacity is limited; 13. currently enrolled in another investigational trial; 14. other situations that are considered not suitable for this clinical research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Catecholamine hormones;Autonomic nerve reaction;Blood glucose;Glucose tolerance;Insulin release;Heart function;Glycated hemoglobin; | — |
Countries
China
Contacts
Public ContactJing Huang
Outcome results
None listed