Chronic cough
Conditions
Interventions
Single cohort:Methoxyphenamine omeprazole domperidone
Sponsors
Shanghai Tongji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 1675years, without gender restrict; 2. History of illness: History of recent illness: course of cough >8years, dry cough or little white sputum, without wheezing or fever. Past history: no history of upper respiratory tract infection in last 2 months; no smoking or withdrawa in last 2 years; no history of occupational dust or toxic or harmful gases exposure; without intake of ACEI in last 3 months; 3. Physical examination: no lung rales; 4. Auxiliary examination: Chest X-ray: no evident abnormality Pulmonary function: FEV1>80% predicted value, and FEV1/FVC>70% predicted value.
Exclusion criteria
Exclusion criteria: 1. Pregnant or breast-feeding women; 2. Allergic to certain drugs; 3. Participants with poor compliance; 4. Respiratory disease: history of occupational dust and toxic or harmful gases exposure; smoking in last 2 years; upper respiratory tract infection in last 2 months; complicated with COPD, interstitial pneumonia and tuberculosis; 5. Other internal disease: uncontrolled hypertension, intaking ACEI in last 3 months, serious arrhythmia, unstable blood sugar, serious hyperthyroidism or hypothyroidism, active digestive ulcer, decompensate cirrhosis, intestinal obstruction, serioud renal and hematological abnormality, thrombus syndrome and untreated seizure; 6. Psychiatric disease; 7. Surgical disease: serious difficulty urinating and recent operation history; 8. Ophthalmologic disease: glaucoma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood routine, liver and renal function;Cough Symptoms Score; | — |
Countries
China
Contacts
Public ContactZhongmin Qiu
Outcome results
None listed