Gastroesophageal reflux induced cough (GERC)
Conditions
Interventions
One cohort:Omeprazole, domperidone, ranitidine.
Sponsors
Shanghai Tongji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Chronic cough with or without the typical upper gastrointestinal symptoms such as regurgitation, heartburn and chest pain; 2) multi-channel intraluminal impedance combined with pH monitoring (MII-pH) confirmed abnormal acid or non-acid reflux, as shown by DeMeester score of >=14.72 and/or syndrome association probability (SAP) for acid or non-acid reflux of >=95%; 3) cough fails to improve with 2 months of standard anti-reflux treatment consisting of omeprazole 20 mg, twice daily, plus domperidone 10 mg, three times a day, but disappears or improves with the consequent intensified anti-reflux regimen.
Exclusion criteria
Exclusion criteria: The other cause of chronic cough such as upper airway cough syndrome, cough variant asthma and eosinophilic bronchitis are excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cough symptom score;reflux symptom score; | — |
Countries
China
Contacts
Public ContactZhongmin Qiu
Outcome results
None listed